Wound healing is a conserved evolutionary process among species and encompasses spatially and temporally overlapping processes including inflammation, blood clotting, and cellular proliferation and extracellular matrix (ECM) remodeling (Seifert et al. 2012b; Richardson et al. 2013). However, the outcome of wound healing in the skin differs between species. Some lower vertebrates including fish (zebrafish) and amphibians (axolotl and Xenopus) possess the ability to perfectly regenerate skin. It is known that after full-thickness excisional wounds in Xenopus froglets and axolotols, the entire skin, including secretory appendages, regenerates (Yokoyama et al. 2011; Seifert et al. 2012b). During this process, even the pigmentation pattern of the skin can be fully re-established (Seifert et al. 2012b). Zebrafish skin can also recover its striped pigmentation pattern following wounding, as well as regenerate subcutaneous adipocytes and scales during the healing process, making the regenerated skin almost indistinguishable from the original one (Richardson et al. 2013).
RB: Axolotl Torrent Download [key]
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